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Viser: An Introduction to Medicinal Chemistry

An Introduction to Medicinal Chemistry, 6. udgave

An Introduction to Medicinal Chemistry

Graham Patrick
(2017)
Sprog: Engelsk
Oxford University Press, Incorporated
520,00 kr. 468,00 kr.
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Detaljer Om Varen

  • 6. Udgave
  • Undefined: 888 sider
  • Udgiver: Oxford University Press, Incorporated (Juni 2017)
  • ISBN: 9780198749691
For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugsactually work? Furthermore, by what processes are new drugs discovered and brought to market?An Introduction to Medicinal Chemistry, sixth edition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Part one of the book introduces the principles ofdrug action via targets such as receptors and enzymes. The book goes on to explore how drugs work at the molecular level (pharmacodynamics), and the processes involved in ensuring a drug meets its target (pharmacokinetics). Further sections cover the processes by which drugs are discovered anddesigned, and what has to happen before a drug can be made available to the public. The book concludes with a selection of current topics in medicinal chemistry, and a discussion of various key drug groups. The subject is brought to life throughout by engaging case studies highlighting particulardrugs and the stories behind their discovery and development.The Online Resource Centre features:For students:* Multiple Choice Questions to support self-directed learning* Web articles describing recent developments in the field and further information on topics covered in the book* Journal Club to encourage students to critically analyse the research literature* Molecular Modelling Exercises, with new exercises in Chem3D* New assignments to help students develop data analysis and problem solving skillsFor registered adopters of the book:* A test bank of additional multiple-choice questions, with links to relevant sections in the book* Answers to end-of-chapter questions.* Figures from the book, ready to download.* Power Point slides to accompany every chapter in the book.

1: Drugs and drug targets - an overviewPart A Drug targets - structure and function2: Protein structure and function3: Enzymes: structure and function4: Receptors: structure and function5: Receptors and signal transduction6: Nucleic acids: structure and functionPart B Pharmacodynamics and pharmacokinetics7: Enzymes as drug targets8: Receptors as drug targets9: Nucleic acids as drug targets10: Miscellaneous drug targets11: Pharmacokinetics and related topicsCase study
1: StatinsPart C Drug discovery, design, and development12: Drug discovery: finding a lead13: Drug design: optimizing target interactions14: Drug design: optimizing access to the target15: Getting the drug to marketCase study
2: The design of ACE inhibitorsCase study
3: Artemisinin and related antimalarial drugsCase study
4: The design of oxamniquinePart D Tools of the trade16: Combinatorial synthesis17: Computers in medicinal chemistry18: Quantitative structure-activity relationships (QSAR)Case study
5: De novo design of a thymidylate synthase inhibitorPart E Selected topics in medicinal chemistry19: Antibacterial agents20: Antiviral agents21: Anticancer agents22: Cholinergics, anticholinergics, and anticholinesterases23: Drugs acting on the adrenergic nervous system24: Opioid analgesics25: Antiulcer agents26: Cardiovascular drugsCase study
6: Steroidal anti-inflammatory agentsCase Study
7: Design of a novel antidepressantCase Study
8: The design and development of aliskirenCase Study
9: Factor Xa inhibitorsCase Study
10: Reversible inhibitors of HCV NS3-4A proteaseAppendices
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