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Viser: An Introduction to Medicinal Chemistry

An Introduction to Medicinal Chemistry, 6. udgave

An Introduction to Medicinal Chemistry

Graham Patrick
(2023)
Oxford University Press
620,00 kr.
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Denne bog er blevet erstattet af An Introduction to Medicinal Chemistry, 7. udgave

Detaljer om varen

  • 6. Udgave
  • Undefined: 832 sider
  • Udgiver: Oxford University Press (Januar 2023)
  • ISBN: 9780198749691
For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs actually work? Furthermore, by what processes are new drugs discovered and brought to market?

An Introduction to Medicinal Chemistry, sixth edition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Part one of the book introduces the principles of drug action via targets such as receptors and enzymes. The book goes on to explore how drugs work at the molecular level (pharmacodynamics), and the processes involved in ensuring a drug meets its target (pharmacokinetics). Further sections cover the processes by which drugs are discovered and designed, and what has to happen before a drug can be made available to the public. The book concludes with a selection of current topics in medicinal chemistry, and a discussion of various key drug groups. The subject is brought to life throughout by engaging case studies highlighting particular drugs and the stories behind their discovery and development.

The Online Resource Centre features:

For students:
DT Multiple Choice Questions to support self-directed learning
DT Web articles describing recent developments in the field and further information on topics covered in the book
DT Journal Club to encourage students to critically analyse the research literature
DT Molecular Modelling Exercises, with new exercises in Chem3D
DT New assignments to help students develop data analysis and problem solving skills

For registered adopters of the book:

DT A test bank of additional multiple-choice questions, with links to relevant sections in the book
DT Answers to end-of-chapter questions.
DT Figures from the book, ready to download.
DT Power Point slides to accompany every chapter in the book.

1: Drugs and drug targets - an overviewPart A Drug targets - structure and function
2: Protein structure and function
3: Enzymes: structure and function
4: Receptors: structure and function
5: Receptors and signal transduction
6: Nucleic acids: structure and functionPart B Pharmacodynamics and pharmacokinetics
7: Enzymes as drug targets
8: Receptors as drug targets
9: Nucleic acids as drug targets
10: Miscellaneous drug targets
11: Pharmacokinetics and related topics Case study
1: StatinsPart C Drug discovery, design, and development
12: Drug discovery: finding a lead
13: Drug design: optimizing target interactions
14: Drug design: optimizing access to the target
15: Getting the drug to market Case study
2: The design of ACE inhibitors Case study
3: Artemisinin and related antimalarial drugs Case study
4: The design of oxamniquinePart D Tools of the trade
16: Combinatorial synthesis
17: Computers in medicinal chemistry
18: Quantitative structure-activity relationships (QSAR) Case study
5: De novo design of a thymidylate synthase inhibitorPart E Selected topics in medicinal chemistry
19: Antibacterial agents
20: Antiviral agents
21: Anticancer agents
22: Cholinergics, anticholinergics, and anticholinesterases
23: Drugs acting on the adrenergic nervous system
24: Opioid analgesics
25: Antiulcer agents
26: Cardiovascular drugs Case study
6: Steroidal anti-inflammatory agents Case Study
7: Design of a novel antidepressant Case Study
8: The design and development of aliskiren Case Study
9: Factor Xa inhibitors Case Study
10: Reversible inhibitors of HCV NS3-4A proteaseAppendices
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