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Viser: Drug-Like Properties: Concepts, Structure Design and Methods - From ADME to Toxicity Optimization
Drug-Like Properties: Concepts, Structure Design and Methods
From ADME to Toxicity Optimization
Li Di og Edward H. Kerns
(2008)
Sprog: Engelsk
Detaljer om varen
- Hardback: 552 sider
- Udgiver: Elsevier Science & Technology (Marts 2008)
- Forfattere: Li Di og Edward H. Kerns
- ISBN: 9780123695208
The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties.
* Serves as an essential working handbook aimed at scientists and students in medicinal chemistry
* Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies
* Discusses improvements in pharmacokinetics from a practical chemist's standpoint