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Foreword xv Preface xvii 1 Introduction 1 Yu-Feng Li and Hongzhe Sun
1.1 A Brief Introduction to Metallomics 1
1.2 Key Issues and Challenges in Metallomics 3
1.3 About the Structure of this Book 4 2 Nanometallomics 11 Hongxin Xie, Liming Wang, Jiating Zhao, Yuxi Gao, Bai Li, and Yu-Feng Li
2.1 The Concept of Nanometallomics 11
2.2 The Analytical Techniques in Nanometallomics 12
2.3 The Application of Nanometallomics in Nanotoxicology 17
2.4 Conclusions and Perspectives 21 3 Environmetallomics 33 Lihong Liu, Ligang Hu, Baowei Chen, Bin He, and Guibin Jiang
3.1 The Concept of Environmetallomics 33
3.2 The Analytical Techniques in Environmetallomics 34
3.3 The Application of Environmetallomics in Environmental Science and Ecotoxicological Science and the Perspectives 43 4 Agrometallomics 49 Xuefei Mao, Xue Li, Tengpeng Liu, and Yajie Lei
4.1 The Concept of Agrometallomics 49
4.2 Analytical Techniques in Agrometallomics 52
4.3 Application and Perspectives of Agrometallomics in Agricultural Science and Food Science 127 5 Metrometallomics 153 Liuxing Feng
5.1 The Concept of Metrometallomics 153
5.2 The Analytical Techniques in Metrometallomics 154
5.3 The Application of Metrometallomics in Life Science and the Perspectives 159 6 Medimetallomics and Clinimetallomics 193 Guohuan Yin, Ang Li, Meiduo Zhao, Jing Xu, Jing Ma, Bo Zhou, Huiling Li, and Qun Xu
6.1 The Concept of Medimetallomics and Clinimetallomics 193
6.2 The Analytical Techniques in Medimetallomics and Clinimetallomics 195
6.3 The Application of Medimetallomics and Clinimetallomics in Medical and Clinical Science and the Perspectives 204 7 Matermetallomics 237 Qing Li, Zhao-Qing Cai, Wen-Xin Cui, and Zheng Wang
7.1 The Concept of Matermetallomics 237
7.2 The Analytical Techniques in Matermetallomics 243
7.3 The Application of Matermetallomics in Material Science and the Perspectives 256 8 Archaeometallomics 265 Li Li, Yue Zhou, Sijia Li, Lingtong Yan, Heyang Sun, and Xiangqian Feng
8.1 The Concept of Archaeometallomics 265
8.2 The Analytical Techniques in Archaeometallomics 266
8.3 The Application of Archaeometallomics in Archaeological Science 269
8.4 Summary and Perspectives 279 9 Metallomics in Toxicology 285 Ruixia Wang, Ming Gao, Jiahao Chen, Mengying Qi, and Ming Xu
9.1 Metallomic Research on the Toxicology of Metals 285
9.2 Recent Progresses in Understanding the Health Effects of Heavy Metals 287
9.3 Knowledge Gaps, Challenges, and Perspectives 297 10 Pathometallomics: Taking Neurodegenerative Disease as an Example 311 Xiubo Du, Xuexia Li, and Qiong Liu
10.1 Introduction to Pathometallomics 311
10.2 Application of Pathometallomics in Neurodegenerative Diseases 314
10.3 The Perspectives of Pathometallomics 338 11 Oncometallomics: Metallomics in Cancer Studies 349 Xin Wang, Chao Li, and Yu-Feng Li
11.1 Introduction to Oncometallomics 349
11.2 The Application of Oncometallomics in Cancer Studies 351
11.3 The Metallome that Involved in the Occurrence and Development of Cancer 355
11.4 Conclusions and Perspectives 356 12 Bio-elementomics 363 Dongfang Wang, Jing Wu, Bing Cao, Lailai Yan, Qianqian Zhao, Tiebing Liu, and Jingyu Wang
12.1 Introduction 363
12.2 Basic Laws of Bio-elementomics 364
12.3 Rare-Earth Elementome 367
12.4 Limitations of Bio-elementomics 371
12.5 Perspectives 373 13 Methodology and Tools for Metallomics 377 Xiaowen Yan, Ming Xu, and Qiuquan Wang
13.1 Brief Description of Metallomics 377
13.2 Methodologic Strategy for Metallomic Research 380
13.3 Tools for Metallomics 383
13.4 Concluding Remarks 387 14 ICP-MS for Single-Cell Analysis in Metallomics 391 Man He, Beibei Chen, and Bin Hu
14.1 Introduction 391
14.2 ICP-MS Instrumental Optimization for Single-Cell Analysis 392
14.3 Microfluidic Platform for Single-Cells Analysis 401
14.4 ICP-MS-Based Single-Cells Analysis in Metallomics 408
14.5 Summary and Perspectives 419 15 Novel ICP-MS-based Techniques for Metallomics 429 Panpan Chang and Meng Wang
15.1 Introduction 429
15.2 ICP-MS: A Powerful Method in Metallomics 430
15.3 Recent Advances in ICP-MS-based Metallomics 433
15.4 Conclusions 442 16 Machine Learning for Data Mining in Metallomics 449 Wei Wang and Xin Wang
16.1 Data Mining Methods in Metallomics 450
16.2 Application of Machine Learning for Data Mining in Metallomics 463 References 469 Index 471