Hjem

Preface Foreword Edmond Fischer SECTION I. GENERAL PRINCIPLES AND MECHANISMS 1 Signals and Receptors Carl-Henrik Heldin, Benson Lu, Ron Evans, and J. Silvio Gutkind 2 Protein Regulation in Signal Transduction Michael J. Lee and Michael B. Yaffe 3 Second Messengers Alexandra C. Newton, Martin D. Bootman, and John D. Scott 4 Signaling Networks: Information Flow, Computation, and Decision Making Evren U. Azeloglu and Ravi Iyengar SECTION II. SIGNALING PATHWAYS MAP Kinase Pathways Deborah K. Morrison The PI3K-PKB/Akt Pathway Brian A. Hemmings and David F. Restuccia mTOR Signaling Mathieu Laplante and David M. Sabatini Calcium Signaling Martin D. Bootman The Cyclic AMP Pathway Paolo Sassone-Corsi Wnt Signaling Roel Nusse Hedgehog Signaling Philip W. Ingham Notch Signaling Raphael Kopan Signaling by the TGFb Superfamily Jeffrey L. Wrana The JAK/STAT Pathway Douglas A. Harrison Toll-Like Receptor Signaling Kian-Huat Lim and Louis M. Staudt Immunoreceptor Signaling Lawrence E. Samelson Signaling by Nuclear Receptors Richard Sever and Christopher K. Glass The Hippo Pathway Kieran F. Harvey and Iswar K. Hariharan SECTION III. SIGNALING PROCESSES 5 Signaling Pathways that Control Cell Proliferation Robert J. Duronio and Yue Xiong 6 Signaling Pathways that Regulate Cell Division Nicholas Rhind and Paul Russell 7 Signaling in Control of Cell Growth and Metabolism Patrick S. Ward and Craig B. Thompson 8 Signaling Networks that Regulate Cell Migration Peter Devreotes and Alan Rick Horwitz 9 Signaling Pathways in Cell Polarity Luke Martin McCaffrey and Ian G. Macara 10 Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning Norbert Perrimon, Chrysoula Pitsouli, and Ben-Zion Shilo 11 Signaling by Sensory Receptors David Julius and Jeremy Nathans 12 Synaptic Signaling in Learning and Memory Mary B. Kennedy 13 Signaling in Muscle Contraction Ivana Y. Kuo and Barbara E. Ehrlich 14 Organismal Carbohydrate and Lipid Homeostasis D. Grahame Hardie 15 Signaling in Innate Immunity and Inflammation Kim Newton and Vishva M. Dixit 16 Signaling in Lymphocyte Activation Doreen Cantrell 17 Vertebrate Reproduction Sally Kornbluth and Rafael Fissore 18 Cell Signaling and Stress Responses Gökhan S. Hotamisligil and Roger J. Davis 19 Cell Death Signaling Douglas R. Green and Fabien Llambi 20 Subversion of Cell Signaling by Pathogens Neal M. Alto and Kim Orth 21 Signal Transduction in Cancer Richard Sever and Joan S. Brugge 22 Outlook Jeremy Thorner, Tony Hunter, Lewis C. Cantley, and Richard Sever Index