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Viser: Signal Transduction: Principles, Pathways, and Processes
Signal Transduction: Principles, Pathways, and Processes
Lewis Cantley, Tony Hunter, Richard Sever og Jeremy Thorner
(2014)
Sprog: Engelsk
Cold Spring Harbor Laboratory Press
1.433,00 kr.
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Detaljer om varen
- Hardback: 452 sider
- Udgiver: Cold Spring Harbor Laboratory Press (Maj 2014)
- Forfattere: Lewis Cantley, Tony Hunter, Richard Sever og Jeremy Thorner
- ISBN: 9780879699017
Cells must respond to a wide variety of signals. These include hormones, growth factors, morphogens, and environmental stress, as well as signals from internal regulators and checkpoints. A complex network of signal transduction pathways within the cell ensures that these signals are relayed to the correct molecular targets and that the cell responds appropriately.
This textbook provides a comprehensive view of signal transduction, covering both the fundamental mechanisms involved and their roles in key biological processes. Taking a novel approach, it first lays out the basic principles of signal transduction, explaining how different receptors receive information and transmit it via signaling proteins, ions, and second messengers. It then surveys the major signaling pathways that operate in cells, before examining in detail how these function in processes such as cell growth and division, cell movement, metabolism, development, reproduction, the nervous system, and immune function.
The book is essential reading for students learning about signal transduction for the first time. It will also be a vital reference for all cell, molecular, and developmental biologists and pharmacologists, neurobiologists, and immunologists studying processes regulated by cell signaling.
This textbook provides a comprehensive view of signal transduction, covering both the fundamental mechanisms involved and their roles in key biological processes. Taking a novel approach, it first lays out the basic principles of signal transduction, explaining how different receptors receive information and transmit it via signaling proteins, ions, and second messengers. It then surveys the major signaling pathways that operate in cells, before examining in detail how these function in processes such as cell growth and division, cell movement, metabolism, development, reproduction, the nervous system, and immune function.
The book is essential reading for students learning about signal transduction for the first time. It will also be a vital reference for all cell, molecular, and developmental biologists and pharmacologists, neurobiologists, and immunologists studying processes regulated by cell signaling.
Preface
Foreword
Edmond Fischer
SECTION I. GENERAL PRINCIPLES AND MECHANISMS 1 Signals and Receptors Carl-Henrik Heldin, Benson Lu, Ron Evans, and J. Silvio Gutkind 2 Protein Regulation in Signal Transduction Michael J. Lee and Michael B. Yaffe 3 Second Messengers Alexandra C. Newton, Martin D. Bootman, and John D. Scott 4 Signaling Networks: Information Flow, Computation, and Decision Making Evren U. Azeloglu and Ravi Iyengar
SECTION II. SIGNALING PATHWAYS MAP Kinase Pathways Deborah K. Morrison The PI3K-PKB/Akt Pathway Brian A. Hemmings and David F. Restuccia mTOR Signaling Mathieu Laplante and David M. Sabatini Calcium Signaling Martin D. Bootman The Cyclic AMP Pathway Paolo Sassone-Corsi Wnt Signaling Roel Nusse Hedgehog Signaling Philip W. Ingham Notch Signaling Raphael Kopan Signaling by the TGFb Superfamily Jeffrey L. Wrana The JAK/STAT Pathway Douglas A. Harrison Toll-Like Receptor Signaling Kian-Huat Lim and Louis M. Staudt Immunoreceptor Signaling Lawrence E. Samelson Signaling by Nuclear Receptors Richard Sever and Christopher K. Glass The Hippo Pathway Kieran F. Harvey and Iswar K. Hariharan
SECTION III. SIGNALING PROCESSES 5 Signaling Pathways that Control Cell Proliferation Robert J. Duronio and Yue Xiong 6 Signaling Pathways that Regulate Cell Division Nicholas Rhind and Paul Russell 7 Signaling in Control of Cell Growth and Metabolism Patrick S. Ward and Craig B. Thompson 8 Signaling Networks that Regulate Cell Migration Peter Devreotes and Alan Rick Horwitz 9 Signaling Pathways in Cell Polarity Luke Martin McCaffrey and Ian G. Macara 10 Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning Norbert Perrimon, Chrysoula Pitsouli, and Ben-Zion Shilo 11 Signaling by Sensory Receptors David Julius and Jeremy Nathans 12 Synaptic Signaling in Learning and Memory Mary B. Kennedy 13 Signaling in Muscle Contraction Ivana Y. Kuo and Barbara E. Ehrlich 14 Organismal Carbohydrate and Lipid Homeostasis D. Grahame Hardie 15 Signaling in Innate Immunity and Inflammation Kim Newton and Vishva M. Dixit 16 Signaling in Lymphocyte Activation Doreen Cantrell 17 Vertebrate Reproduction Sally Kornbluth and Rafael Fissore 18 Cell Signaling and Stress Responses Gkhan S. Hotamisligil and Roger J. Davis 19 Cell Death Signaling Douglas R. Green and Fabien Llambi 20 Subversion of Cell Signaling by Pathogens Neal M. Alto and Kim Orth 21 Signal Transduction in Cancer Richard Sever and Joan S. Brugge 22 Outlook Jeremy Thorner, Tony Hunter, Lewis C. Cantley, and Richard Sever
Index
Foreword
Edmond Fischer
SECTION I. GENERAL PRINCIPLES AND MECHANISMS 1 Signals and Receptors Carl-Henrik Heldin, Benson Lu, Ron Evans, and J. Silvio Gutkind 2 Protein Regulation in Signal Transduction Michael J. Lee and Michael B. Yaffe 3 Second Messengers Alexandra C. Newton, Martin D. Bootman, and John D. Scott 4 Signaling Networks: Information Flow, Computation, and Decision Making Evren U. Azeloglu and Ravi Iyengar
SECTION II. SIGNALING PATHWAYS MAP Kinase Pathways Deborah K. Morrison The PI3K-PKB/Akt Pathway Brian A. Hemmings and David F. Restuccia mTOR Signaling Mathieu Laplante and David M. Sabatini Calcium Signaling Martin D. Bootman The Cyclic AMP Pathway Paolo Sassone-Corsi Wnt Signaling Roel Nusse Hedgehog Signaling Philip W. Ingham Notch Signaling Raphael Kopan Signaling by the TGFb Superfamily Jeffrey L. Wrana The JAK/STAT Pathway Douglas A. Harrison Toll-Like Receptor Signaling Kian-Huat Lim and Louis M. Staudt Immunoreceptor Signaling Lawrence E. Samelson Signaling by Nuclear Receptors Richard Sever and Christopher K. Glass The Hippo Pathway Kieran F. Harvey and Iswar K. Hariharan
SECTION III. SIGNALING PROCESSES 5 Signaling Pathways that Control Cell Proliferation Robert J. Duronio and Yue Xiong 6 Signaling Pathways that Regulate Cell Division Nicholas Rhind and Paul Russell 7 Signaling in Control of Cell Growth and Metabolism Patrick S. Ward and Craig B. Thompson 8 Signaling Networks that Regulate Cell Migration Peter Devreotes and Alan Rick Horwitz 9 Signaling Pathways in Cell Polarity Luke Martin McCaffrey and Ian G. Macara 10 Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning Norbert Perrimon, Chrysoula Pitsouli, and Ben-Zion Shilo 11 Signaling by Sensory Receptors David Julius and Jeremy Nathans 12 Synaptic Signaling in Learning and Memory Mary B. Kennedy 13 Signaling in Muscle Contraction Ivana Y. Kuo and Barbara E. Ehrlich 14 Organismal Carbohydrate and Lipid Homeostasis D. Grahame Hardie 15 Signaling in Innate Immunity and Inflammation Kim Newton and Vishva M. Dixit 16 Signaling in Lymphocyte Activation Doreen Cantrell 17 Vertebrate Reproduction Sally Kornbluth and Rafael Fissore 18 Cell Signaling and Stress Responses Gkhan S. Hotamisligil and Roger J. Davis 19 Cell Death Signaling Douglas R. Green and Fabien Llambi 20 Subversion of Cell Signaling by Pathogens Neal M. Alto and Kim Orth 21 Signal Transduction in Cancer Richard Sever and Joan S. Brugge 22 Outlook Jeremy Thorner, Tony Hunter, Lewis C. Cantley, and Richard Sever
Index
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