Sustainability in TIDES Chemistry

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Viser: Sustainability in TIDES Chemistry - Green Approaches to Oligonucleotides and Oligopeptides Synthesis

Green Approaches to Oligonucleotides and Oligopeptides Synthesis

Alessandra Tolomelli, Lucia Ferrazzano og Walter Cabri

(2024)

Sprog: Engelsk

Royal Society of Chemistry, The

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Detaljer om varen

Hardback: 424 sider
Udgiver: Royal Society of Chemistry, The (Oktober 2024)
Forfattere: Alessandra Tolomelli, Lucia Ferrazzano og Walter Cabri
ISBN: 9781837672585

Beskrivelse
Indhold

Oligopeptides and oligonucleotides, jointly defined as TIDES, have been neglected in the past as potential drugs due to their short half-life and practical difficulties in the manufacturing processes. The consolidation of iterative synthetic techniques, allowing for design of new chemical entities with better pharmaceutical profiles, has led to renewed interest in these compounds. Large scale manufacturing is therefore now required, and it is important that sustainability and green chemistry are considered from the outset.

As the two classes display many similarities, advances in sustainable approaches can easily be adapted from one class to the other. This book brings together all of the information on green synthesis of oligopeptides, which is well established, and all of the preliminary data on green oligonucleotides synthesis, creating a resource that will help chemists to bridge the gap between these two areas.

Introduction Green Metrics for a Sustainable Approach in Iterative Processes Recent Trends in Peptide Drug Discovery and Development Sustainable Approaches in Solid-phase Peptide Synthesis (SPPS) Third Wave for Peptide Synthesis: Liquid-phase Peptide Synthesis (LPPS) Sustainable Approaches to Chemo-enzymatic Peptide Synthesis Recombinant and Semisynthesis of Peptides Oligopeptide Regulatory Affairs and Challenges Oligonucleotide Synthesis and State-of-the-Art Drug Discovery Sustainable Approaches in Solid-phase Oligonucleotides Synthesis: Current Status and Future Directions Sustainable Approaches in Liquid-phase Oligonucleotide Synthesis (LPOS) Stereopure Oligonucleotides Impact of Impurities on the Quality and Safety of Oligonucleotides as Drug Substances Oligonucleotide Regulatory Affairs and Challenges Greening Chromatographic Purification Processes

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Viser: Sustainability in TIDES Chemistry - Green Approaches to Oligonucleotides and Oligopeptides Synthesis

Sustainability in TIDES Chemistry

Green Approaches to Oligonucleotides and Oligopeptides Synthesis

Alessandra Tolomelli, Lucia Ferrazzano og Walter Cabri

(2024)

Sprog: Engelsk

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SØG - mellem flere end 8 millioner bøger:

Viser: Sustainability in TIDES Chemistry - Green Approaches to Oligonucleotides and Oligopeptides Synthesis

Sustainability in TIDES Chemistry

Green Approaches to Oligonucleotides and Oligopeptides Synthesis

Alessandra Tolomelli, Lucia Ferrazzano og Walter Cabri

(2024)

Sprog: Engelsk

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